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Symptoms can range from mild irritation to severe, activity-limiting pain

Clinical implications for patients may include: Reduced portion sizes at meals due to earlier satiety Decreased frequency of snacking between meals Diminished cravings for high-calorie, palatable foods Improved ability to adhere to reduced-calorie dietary plans These effects typically develop within the first few weeks of treatment

Japanese Journal of Food Chemistry 8:8393

Schilling Test: The flushing dose is 1,000 mcg

Appetite reduction and more efficient energy use due to activation of three hormone receptors: GLP-1, GIP, and glucagon receptors