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Tirzepatide, a newer GLP-1/GIP dual agonist, and retatrutide, a triple agonist still in trials, have pushed results even further, with average weight loss approaching 2025% of body weight

Murray DB, McLarty-Williams J, Nagalla KT, Janicki JS (2012) Tryptase activates isolated adult cardiac fibroblasts via protease activated receptor-2 (PAR-2)

Because sufficient amounts of IF are needed to bind to B12, and adequate stomach acid is required to activate IF, a deficiency of either can lead to a B12 deficiency and devastating health consequences

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Lilly researchers reported promising mid-stage trial results for an oral pill called orforglipron to treat patients who are obese or overweight with and without diabetes