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Preserving lean mass while reducing fat is important for: Sustained Weight Loss : Muscle helps maintain a higher metabolic rate

Archived from the original on 6 February 2026

High-fat meals sit in your stomach even longer when gastric emptying is already slowed

Instead, they mimic a natural hormone that slows stomach emptying, increases feelings of fullness, and reduces hunger signals in the brainall independent of insulin function

In a head-to-head comparison of the two GLP-1 drugs, adults living with obesity or overweight who were taking Zepbound, the brand name for tirzepatide, lost more than 20% of their weight on average after about a year and half, compared with an average of about 14% weight loss among those taking Wegovy, the brand name for semaglutide

doi: 10.1016/0196-9781(95)02046-2 56 LutzTATschudySRushingPAScharrerE