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Patients can experience generalized tonic-clonic seizures, in which they fall down, shake and become unresponsive

But with increasing popularity comes growing concern

Wan L, Langenberg C, Bellomo R, May CN (2009) Angiotensin II in experimental hyperdynamic sepsis

Glut1 and asct2 as predictors for prognosis of hepatocellular carcinoma

Importantly, these next-generation compounds also suggest that the FBXO22 C326 pocket has some flexibility to accommodate groups larger than an alkyl aldehyde and that other approaches to engage this important nucleophilic residue may be possible