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Melanotan 2 is associated with more frequent and intense nausea in some subject populations compared to PT-141, potentially reflecting its broader melanocortin receptor activation

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Semaglutide is usually taken as a once-weekly injection, while metformin is typically taken orally, either once or twice a day with meals to reduce gastrointestinal discomfort

Patients experiencing persistent mood changes, severe depression, or thoughts of self-harm should seek immediate medical advice