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2 h An 8-week dose-escalation regimen was used, with dose escalation from 0.25 mg per week for 4 weeks then 0.5 mg per week for another 4 weeks, followed by maintenance dose of 1 mg per week throughout remainder of the treatment period

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Vehicle-treated Gipr fl/fl and Gipr Syn/ mice showed a 1.5% and 2.6% weight gain, respectively, whereas mGIPR-Ab/P1-treated Gipr fl/fl mice lost 20% of their body weight (Fig

Using [ 3 H]-labeled BPC157 and radioactivity examination, we proved that the main excretory pathways of BPC157 involved urine and bile