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Disruption of the astrocytic TNFR1-GDNF axis accelerates motor neuron degeneration and disease progression in amyotrophic lateral sclerosis

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Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD

In fact, some early studies and patient reports indicate bloating and abdominal discomfort improve on GLP-1 therapy, likely due to the slowed, more gradual digestive process

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There have been concerns about whether isotretinoin might affect growth, due to case reports of premature closure of the epiphyses (the growth areas at the ends of long bones) in the treatment of neuroblastoma, where much higher doses of this drug are given to younger children than what is typically prescribed for acne