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MOTS-c received favorable 75 votes with two abstentions

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Contraindications exist for patients with seizure disorders, uncontrolled blood pressure, or opioid dependence

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Semaglutide dosing: Starts very low (0.25mg) Slower titration schedule 4-week intervals between increases Maximum 2.4mg weekly More conservative escalation This gentler approach minimizes side effects but means slower initial results