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Mechanisms identified include: increased cardiac utilization of ketones increased autophagy (recycling of intracellular components)l decreased inflammation & oxidative stress improved mitochondrial function decreased intracellular Ca & Na overload decreased fibrosis improved myocardial diastolic function decrease myocardial hypertrophy Figure: Mechanism of action of action of SGLT-2 inhibitors in the kidney

But your mitochondria the powerhouses of your cells have their own DNA, and MOTS-c is one of the most important signals they send

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Genetic deletion of GSK3 in mice results in behaviours that mimic the mood-stabilising effects of lithium, as well as causing cognitive deficits similar to those associated with chronic lithium treatment in humans [166,167,168,169]

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