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The drug became available over the counter in the 1980s and has since become a staple ingredient in more than 300 over-the-counter formulations, including cough medicine and pain relief products

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The most frequently reported side effects include nausea, vomiting, diarrhea, and constipation

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In a rat model of ischemic stroke, administration of the herbal compound Salvia miltiorrhiza extract modulated gut microbiota composition, reduced infarct size, and decreased markers of inflammation and oxidative stress, indicating a gut-mediated neuroprotective effect (Wu J