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Therefore, CB-839 has been tested in many clinical trials, including colorectal cancer (NCT02861300), triple-negative breast cancer (NCT02071862), renal cell carcinoma (NCT03163667), melanoma (NCT02771626), and others (Table 2)

Generally, most GSTs are upregulated rather than downregulated during the resistance reaction, as confirmed in pepper leaves infected with Obuda pepper virus ObPV ( Arabidopsis thaliana (Sun et al., 2016), Beta vulgaris and beet necrotic yellow vein virus-BNYVV interactions ( - CGMMV (Satoh et al., 2013)

Lin J, Li X, Lu K, Song K, Wang L, Dai W, et al

10.4103/1673-5374.293156 40 GaoF.YangS.WangJ.ZhuG

The quantitative polymerase chain reaction (PCR) assay is most widely used now

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