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Vitamin C deficiency and impact of vitamin C administration among pediatric patients with advanced chronic kidney disease

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In this study, we found that statin-induced cell death in YR1.7 and MC38 exhibited key hallmarks of ferroptosis, including downregulation of GPX4 and could be rescued by ferroptosis inhibitors (ferrostatin-1 and liproxstatin-1) for the majority of lipophilic statins

These effects are associated with improved glucose handling rather than direct pharmacological action