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Glucagon-like peptide-1 receptor agonists before upper gastrointestinal endoscopy and risk of pulmonary aspiration or discontinuation of procedure: cohort study

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While these earlier drugs demonstrated the potential of GLP-1 therapy, the newer medications semaglutide, tirzepatide, and retatrutide have completely changed the game

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These agents enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways