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Ex-4 also promotes neurite outgrowth and survival in neurons in the dorsal root ganglion of adult rats through the activation of the PI3K signaling pathway, which in turn suppresses RhoA activity, a negative regulator of nerve regeneration [57]

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Like peptides, they are easily synthesised by iterative coupling on solid support and possess their own secondary, tertiary and quaternary structures based on their sequences 22,23

Ong F, Garcia-Manero G, Montalban-Bravo G, Alvarado Y, Ohanian M, Konopleva M, Jabbour E, Jain N, Borthakur G, DiNardo CD, Daver N, Issa GC, Sasaki K, Chien KS, Takahashi K, Andreeff M , Muftuoglu M, Delumpa R, Mayor E, Loiselle C, Waller L, Banks G, Kantarjian H, Cortes JE, and Short N

Lanzinger S, Laubner K, Warncke K et al (2024) Clinical characteristics, treatment, and treatment switch after molecular-genetic classification in individuals with maturity-onset diabetes of the young: insights from the multicenter real-world DPV registry