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GPX4 is the only cellular enzyme that specifically reduces phospholipid hydroperoxides to lipid alcohols using GSH as a co-factor 4 , and inhibiting the cyst(e)ine/GSH/GPX4 axis induces the strongest cell death in most cellular contexts

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doi: 10.1089/thy.2018.0257 7 DasKChainyGB

N-Acetylcysteine (NAC) for Glutathione Synthesis Support N-acetylcysteine, a precursor to glutathione, provides the rate-limiting cysteine amino acid necessary for glutathione synthesis