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4,6 A key issue in the physiology of type 2 diabetes (T2DM) is the reduced incretin effect, which mainly results from decreased activity of the primary incretin hormones, GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic peptide)

Front Immunol (2021) 12:745535

Concomitant identification of biomarkers for ferroptosis is also required for more rigorous inclusion/exclusion into clinical trials and robust evaluation/formal testing of novel therapies targeting the ferroptotic cascade

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Furthermore, L-Carnitine also helps in the removal of metabolic waste products from the mitochondria, preventing their accumulation which could otherwise impair mitochondrial function