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One interesting theory Ive heard is that in people with a long history of alcohol-use disorder of heavy drinking that the blood-brain barrier becomes leakier, that its easier for different things to cross into the brain, and that, again, this may be one reason that GLP-1s perhaps are more effective in reducing substance use for people with alcohol-use disorder than other drugs

Interestingly, intestinal L cells have been reported to be prone to gluco- and lipotoxicity, with lipotoxicity being associated with activated ER stress response (143)

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Clinical trials proving their effectiveness also included education on nutrition and physical activity, which are essential for achieving meaningful results

Semaglutide, a GLP-1 receptor agonist, is known for its ability to help suppress appetite and support healthy weight loss