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Preclinical murine studies have shown that triagonists, in comparison to dual-incretin co-agonists, more effectively reduced adipose tissue, hepatic steatosis, plasma cholesterol, and improved glucose tolerance while achieving a favorable energy balance by increasing energy expenditure and decreasing food intake

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In addition, the forced and intensive dose escalation with large increments may have impacted potential risk-benefit effects

Clinical research has explored its potential efficacy in reducing body weight, improving glycemic control, and modulating satiety signals

The quantity, quality, and composition of the food consumed, as well as the timing of meals, directly impact human health by influencing the availability of nutrients

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