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GHK was found to upregulate expression of numerous caspase genes, growth regulatory genes, and DNA repair genes associated with anti-cancer activity a finding that suggests GHK-Cus gene regulatory properties extend well beyond regenerative and cosmetic applications

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Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine