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An animal study showed that rats on a ketogenic diet during metabolic adaptation (approximately 3 weeks) exhibited increased production of H 2 O 2 originating from the hippocampus mitochondria and 4-hydroxynonenal (4-HNE), a product of lipid peroxidation

While a direct mechanistic link has yet to be found, CVB infections are known to cause chronic inflammatory diseases, including myocarditis, meningitis, and pancreatitis (137)

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Of the other sites we propose, some are more likely than others, but those in TXNRD1 and SELENOF are particularly convincing, and all of the predicted sites map to surface accessible regions of the targeted proteins (Figure S3)