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Exposure to SGLT2 inhibitors from postnatal day 21 to 90, the period functionally coinciding with the late second and third trimesters of human pregnancy regarding kidney development, caused dilatation of the renal pelvis and tubules ( Table 2 )

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for example, tirzepatide and GLP-1 behave similarly at the mGLP-1R, whereas tirzepatide is less potent at the mGIPR than mGIP