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Changes in Weight at Week 56 and Week 160 for Study 1 (Subset of Patients with Abnormal Blood Glucose at Randomization) SD = Standard Deviation Includes all randomized subjects who had a baseline body weight measurement

5-Amino-1MQ and Muscle Function The effects of NNMT inhibition in muscle tissue mirror those observed in adipose tissue, with increased GLUT4 expression and greater energy turnover