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After full-text assessment, we excluded studies on diabetes mellitus ( n = 154), studies on Parkinson or neurodegenerative conditions ( n = 8), and in vitro, animal and human studies that did not investigate pain as primary and/or secondary outcome ( n = 130)

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"The first is affectionately known as the brain stem's vomit center," Yacawych says

(15) After inducing diabetic osteoporosis through a high fat diet and streptozotocin, light and scanning electron microscopy revealed evidence of bone deterioration via the upregulation of nuclear factor kappa-B ligand (RANKL) and downregulation of pro-osteogenic markers OPG and osteocalcin

Endocrinology 2007

J Am Diet Assoc 1995;95:82-3