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3.4 Glucoselipid metabolism and IR Insulin resistance serves as the crucial hub connecting metabolic derangements and reproductive dysfunction in PCOS, making it a primary target for GLP-1RA intervention within the metabolicreproductive axis

Untreated steroid-induced hyperglycemia increases cardiovascular risk and can progress to steroid-induced diabetes in vulnerable patients

It can also reduce cardiovascular risks by 2.3 percentage points compared to a placebo

Pharmacokinetic modeling in hepatectomy patients shows a 30 % reduction in clearance

The theoretical concern with BPC-157 follows a similar pattern: biological plausibility exists, but demonstrable risk has not materialized

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