In the head-to-head SURMOUNT-5 trial (NEJM, 2025), tirzepatide produced 20.2% body weight loss vs 13.7% for semaglutide at 72 weeks, with similar side-effect profiles
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The authors advocate tailored monitoring protocols, including gradual dose titration at initiation and periodic renal function assessment in elderly patients to optimise safety outcomes in clinical practice
What has been your clinical experience with off-label GLP-1 RA use in PCOS
Evidence of lipid peroxidation by increased levels of malondialdehyde and other such substances such as 8-isoprostane and thiobarbarbituric acid-reactive substance levels is one of the primary means by which researchers have associated oxidative processes with an overall decrease of cellular function
California drivers can attend traffic school to keep points off their license, but this option is available only for minor offenses like running a stop sign or failing to yield the right-of-way
