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Consensus Clinical Guide, June 2024

Physiology or pharmacology

Do you have a positive outlook

Absolute contraindications Do not use compounded semaglutide with B12 if you have: A personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to semaglutide or cyanocobalamin Leber hereditary optic neuropathy (a contraindication specific to the cyanocobalamin component) Active pregnancy (semaglutide showed embryofetal toxicity in animal studies) Understanding drug interactions is especially important for people using peptide therapy broadly, as multiple compounds can produce unpredictable interactions

These are FDA approved to treat Type 2 Diabetes, but healthcare providers may prescribe them off-label for weight loss

Adopt a Balanced Diet: Focus on nutrient-dense foods and controlled portions