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The overall reaction is: 6 Glucose 6-phosphate + ATP 6 Ribose 5-phosphate + ADP + H + Under these metabolic conditions, there is a functional interplay between glycolysis and the non-oxidative phase of the pentose phosphate pathway, with the latter running in the direction of ribose 5-phosphate synthesis

It may be especially relevant when excess fat is contributing to higher estrogen conversion

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This is the reason why we discuss electron donors and acceptors rather than hydrogen donors and acceptors.

Richardson SJ, Rodriguez-Calvo T, Gerling IC et al (2016) Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes