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Lee HW, Ang L, Choi J, Lee MS

Following a review completed in 2024, the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) concluded that available evidence did not support a causal link between GLP-1 receptor agonists and suicidal ideation or self-harm, a conclusion also reflected in MHRA communications that year

however, the methods used to investigate such a relationship have been limited [16]

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Polysaccharides are the biologically active macromolecules formed by monosaccharides linked by glycosidic bonds, which are formed by polyhydroxy polymers and their derivatives

Obesity has been previously connected to a concept known as reward deficiency syndrome, where individuals with obesity have intrinsically decreased activity of the brains reward circuitry, leading to hyperphagia of highly palatable foods that contribute to significant increases in energy intake [19]