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Notably, the molecular composition of exosomes exhibits significant parental cell dependence. For instance, tadalafil preconditioning can upregulate the expression of miR-29a-3p in MSC-derived exosomes, thereby enhancing their therapeutic efficacy (Liu et al., 2024d)

Welsh JW, Seyedin SN, Hofstetter WL, Ajani JA, Chang JY, Gomez DR, Swisher SG , Blum MA, Nguyen Q, Minsky BD, Erasmus J, Lee JH, Bhutani MS, Komaki RU

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