It plays several important roles in metabolic health, including signalling to your brain that you're full, slowing down how quickly food leaves your stomach, and helping your pancreas release the right amount of insulin to manage blood sugar levels
Such mechanisms are particularly relevant to PCOS, where systemic oxidative stress, hyperinsulinemia, and androgen excess establish a pre-activated metabolic state that lowers the threshold for both NOX2- and mitochondria-dependent NET formation (61)
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however, in individuals with existing insulin resistance, the same dose of BCAAs may exacerbate metabolic abnormalities (112)
In vitro, pycnogenol has antioxidant properties that are more potent than vitamins E and C