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S-Adenosylmethionine and Methylation S-Adenosylmethionine (also known as SAM-e, SAMe, SAM, AdoMet, or ademetionine) is a critical metabolite found in all living cells

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Using them together covers both bases

Table 2 Across pathway correlations between 6 purine and 14 monoamine metabolites by the Kendalls tau method

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