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In animal models, it upregulates the anti-apoptotic protein Bcl-2, downregulates the pro-apoptotic protein Bax, alters mitochondrial membrane permeability, and inhibits the activation of executioner caspases such as caspase-3, thereby blocking the apoptotic signaling pathway ( 3.4 Immunomodulatory mechanisms Glycyrrhizin exhibits multiple immunomodulatory mechanisms

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Studies show silymarin has been shown to increase glutathione levels and prevent depletion (4)

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