It is important to remember that the medication is already at work internally, stabilizing blood sugar levels and beginning the process of signaling satiety to the brain, even if the total loss of cravings hasnt fully peaked yet
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Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances (Chang et al., 2007)
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Loss of Lean Muscle Mass Rapid weight loss associated with GLP-1 therapy typically includes a proportion of skeletal muscle mass, which can impair basal metabolic rate, physical function, and glucose disposal