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The final pathological manifestation of CKD is renal fibrosis, characterized by glomerulosclerosis, renal tubular atrophy, and interstitial fibrosis [223, 224]

GHK-Cu was also shown to play a role in ischemic and diabetic wound healing in rats, as well as decreasing TNF-alpha levels and increasing collagen synthesis ( Anti-Inflammatory Effects of GHK-Cu As it was mentioned above, GHK-Cu is shown to have antioxidant and anti-inflammatory properties

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Individual treatment groups were: (1) DMSO vehicle control (0.0003%, corresponding to the DMSO concentration in the high BPA group), (2) water control, (3) 0.001 M (low) BPA, and (4) 0.1 M (high) BPA

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AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1