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Studies suggest reduced inflammation and oxidative stress, but more data are needed

Statistical analysis All data were statistically analyzed using GraphPad Prism 8.0, SPSS, and R software and presented by Adobe Illustrator

It also increases the production of stem cells and supports bone repair, suggesting systemic regenerative activity beyond dermatological applications

In vitro study found that topiramate increased MDA, NO and ROS production in astrocytes, showing a dose-dependent negative effect (Pavone and Cardile, 2003)

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