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GLP-1s functions inside our heads include regulating insulin signalling in the brain

Alterations in key metabolic pathways such as glycolysis and oxidative phosphorylation profoundly affect the activation, differentiation and function of B and T cells, monocytes, neutrophils and other immune cells, driving inflammation and tissue injury

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Mast cells in the skin degranulate in response to the injected medication, releasing histamine that activates nerve endings and creates that maddening itch

No earlier pharmacologic class has produced double-digit percentage weight reductions sustained over 68 to 88 weeks in large, placebo-controlled cohorts

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