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A novel HDAC/MIF dual-target inhibitor (6a) at a concentration of 12.5 M promotes apoptosis by inhibiting HDAC activity and inducing histone acetylation (H3K27ac), while simultaneously blocking the MIF-CXCR7-AKT signaling pathway, thereby synergistically inhibiting the survival and proliferation of NSCLC cells (especially EGFR-mutant/TKI-resistant strains)

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With a 5-day half-life and steady-state accumulation of approximately 1.6-fold, the drug maintains consistent plasma levels throughout the dosing interval