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It could effectively attenuate cisplatin-induced hearing loss by inhibiting the transient receptor potential vanilloid receptor 1 (TRPV1)/Ca 2+ /calpain-oxidative stress pathway without compromising the antitumor efficacy of Cisplatin (Di et al

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175 Arginine-succinate synthetase 1 (ASS1) transcriptional repression occurs in various tumors, creating a dependence on external arginine and enabling arginine-deprivation therapy