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Others Additionally, other studies have demonstrated that OS is present in dogs with ischemia-reperfusion injury [230], as well as in systemically ill dogs undergoing hospitalization due to various underlying disorders (e.g., infectious, inflammatory, immune-mediated, metabolic, and neoplastic) [231,232]

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Additionally, significant improvements in OS biomarkers have been observed following antioxidant supplementation with N-acetylcysteine [113] and Fibroblast growth factor-21 [112]