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These promising results led to the development of the first dual agonists, with tirzepatide, a GIP and GLP-1 receptor agonist, being the most prominent one
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However, the half-life of natural GLP-1 in plasma is less than 2 min because it is rapidly enzymatically degraded by DPP-IV
Bloodwork provides a useful baseline
Peptides natural approach provides balanced and prolonged effects