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The PERK-ATF4 pathway induces the expression of multiple vascular endothelial growth factors, including VEGFA, VEGFB, VEGFC, VEGFD, VEGFF, and placental growth factor, which collectively support endothelial cell survival, neovascularization, and sustained tumor growth

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579 In addition, metabolic disorders of neuronal Ca 2+ can drive ferroptosis through interactions with iron and crosstalk between the ER and mitochondria, and maintaining Ca 2+ homeostasis to inhibit ferroptosis may be an innovative target for the treatment of AD

PMID 435643

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