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PMID 32462512

It is currently being marketed under the brand name Mounjaro as a medication for Type 2 Diabetes, they are seeking FDA approval for weight loss

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The 28% average body weight reduction observed in retatrutides Phase 3 programme, alongside an 82.4% reduction in liver fat in MASLD participants, positions it as the most potent incretin-based compound currently in late-stage development [2][4]

When this transition to burning fat preferentially occurs it results in the production of ketones which can be measured in the urine as proof that you are successfully burning fat

8 Cryo-EM data processing workflow for S-4048-bound SLC37A4-BRIL/Fab/Nb (monomer)