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STEP-1, a 2021 study in New England Journal of Medicine , tested weekly semaglutide 2.4 mg (the molecule in Wegovy) in adults with overweight or obesity
[DOI] [PubMed] [Google Scholar] 172.Fontes L.E.S., Martimbianco A.L.C., Zanin C., Riera R
& Cianflone, K
Start your intake What Does GLP-1 Non-Response Actually Mean GLP-1 non-response occurs when a patient follows a consistent semaglutide protocol but loses less than 5% of their starting body weight after 12 weeks or experiences weight loss plateau before reaching therapeutic goals
Compared with patients taking non-GLP-1 diabetes medications, GLP-1 users had a 14% lower risk of developing any substance use disorder
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