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On the flip side, many people with obesity may already have an abnormal menstrual cycle, and taking Zepbound could potentially help restore a more regular period

This translated to an absolute average weight reduction of approximately 52 pounds per participant

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Transdermal delivery requires ingredients to cross the stratum corneum, the outermost layer of skin, which is specifically designed to keep foreign substances out

In the phase 2 NEJM trial, participants receiving the highest dose of retatrutide (12 mg) achieved a mean body weight reduction of approximately 24.2% from baseline at 48 weeks, compared with approximately 2.1% in the placebo group