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The real concern about muscle loss during semaglutide use stems from very rapid weight loss in some patients

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doi: 10.3389/fimmu.2019.01027 158 KinseySGNaiduPSCravattBFDudleyDTLichtmanAH

Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship