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In contrast, RhoA activating kinase (ROK) phosphorylates PRMT5 at T80 enhancing its activity on H4R3me2s and activating proto-oncogenes, contributing to tumor formation in hepatocellular carcinoma

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Additionally, in-vivo and in-vitro studies show ALA exhibits antioxidant properties, reduces UV-induced inflammation, and supports wound healing

Furthermore, higher levels of IGF-1 are associated with higher bone mineral density in adult obese individuals (230)

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In addition, PRMT1 and PRMT5 exhibit overlapping substrate specificity, and they can competitively modify the same substrates, effectively substituting for each other to perform similar methyltransferase functions on the same substrate [21]