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doi: 10.6133/apjcn.2016.25.2.22

Furthermore, actively cycling CAR T cells isolated from a patient with a decade-long leukemia remission showed upregulation in LDHA and OXPHOS pathways, suggesting that both aerobic glycolysis and mitochondrial respiration are increased in CAR T cells that persist long-term 25

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This context-dependency implies that the specific effects of senescence might differ across various tissues and diseases