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Highlights Sodium-glucose cotransporter-2 inhibitors (SGLT2-i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) provide modest but clinically meaningful blood pressure (BP) lowering effects in people with hypertension and cardiometabolic comorbidities

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Genetic ablation of MCT1 in T cells leads to impaired CD8 + T cell proliferation, a shift in energy metabolism toward oxidative phosphorylation, and a notable reduction in effector T cell accumulation within epididymal white adipose tissue (eWAT)

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