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R747W is a mutant phenotype with loss-of-function of the gene encoding iPLA2, which reduces the hydrolytic activity of 15-HpETE-PE, and increases the content of 15-HpETE-PE in cells, and increases the sensitivity to ferroptosis compared with the wild type

Hence, subsequent trials administered GDNF through either parenchymal infusions into the striatum 48 or via gene therapy to transfect the host, but with overall negative results 10,40,50

Large-scale genetic correlation scanning and causal association between deep vein thrombosis and human blood metabolites

Beyond simply blocking histamine release, these flavonoids actively suppress the production of newly synthesized inflammatory mediators