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Liraglutide 1.8 mg daily reduced 3-point MACE by 13% vs placebo (HR 0.87, 95% CI 0.78-0.97, p=0.01)

In mice, overexpression of 11-HSD1disrupted lipid metabolism, resulting in significantly elevated serum levels of CORT, cholesterol (CHO), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) compared to the control group

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